APOE ε4 predicts risk of future depression

The ApoE4 variant, apparently predominant in pre-modern hominids, is a known genetic risk factor for impaired lipid regulation leading to elevated cholesterol, triglycerides and poor modulation of inflammation and oxidative stress predisposing an individual to a range of abnormal conditions from vascular disease to Alzheimer’s disease. Now linked also to depression. More here; even more here.